Medicube One Day Exosome Shot 2000 | At-Home Microneedling Meets K-Beauty Science
You've seen it all over Tiktik. You've wondered if it actually works. It does.
The Medicube One Day Exosome Shot 2000 is unlike any serum in your current routine. While most ampoules sit on the skin's surface and wait to be absorbed, this one takes a radically different approach — using 15 million micro-sized, needle-shaped spicule particles to physically drive active ingredients deep into the pore, mimicking the professional results of a clinic-grade microneedling treatment from the comfort of your own home.
The tingling you feel on application? That's not a warning sign. That's confirmation the formula is working.
What Are Exosomes — And Why Do They Matter?
Exosomes are naturally occurring nano-sized particles produced by living cells. Think of them as the body's internal messaging system — tiny carriers that transport proteins, amino acids, peptides, and genetic signals between cells to trigger repair, renewal, and regeneration.
In this formula, Medicube uses Lacto Exosomes derived from Lactobacillus — a well-studied beneficial bacteria strain. These fermentation-derived exosomes are loaded with peptides, amino acids, glutathione, and vitamins that communicate directly with skin cells, encouraging them to repair damage, strengthen the barrier, and function more efficiently. At a concentration of 2000ppm, the Exosome Shot 2000 delivers a meaningful, effective dose — potent enough to produce visible results, while still being accessible for those newer to exosome skincare.
The Spicule Technology: Home Microneedling, Reinvented
The real innovation in this formula is the Hydrolyzed Sponge (Spicule) — microscopic, needle-shaped particles derived from natural marine sponge. When applied and massaged into the skin, these micro-needles create invisible micro-channels in the skin's surface, allowing active ingredients to bypass the outer barrier and reach the deeper dermal layers where they can actually make a difference.
This is the mechanism behind the product's clinically validated claim that it enhances skincare absorption by 242% compared to using cosmetics alone. Your other skincare products don't just sit on top — they go deeper too, making your entire routine more effective in the process.
The spicules shed naturally with dead skin cells over the days following application, meaning no rinsing is required and no residue remains in the skin.
Key Ingredients & What They Do
Lactobacillus Extracellular Vesicles (Lacto Exosomes) are the hero of the formula. These fermentation-derived nano-particles carry a concentrated payload of skin-renewing compounds directly to the cell level, where they help accelerate natural repair, boost resilience, and visibly improve the overall condition of the skin with continued use.
Hydrolyzed Sponge (Spicules) form the micro-needle delivery system. These natural marine-derived particles open micro-channels in the skin's surface to maximise the depth and efficiency of active ingredient penetration.
Niacinamide (Vitamin B3) is one of the most researched brightening and barrier-boosting actives in skincare. It works to even skin tone, reduce the visibility of enlarged pores, increase ceramide production for a stronger moisture barrier, and calm inflammation — making it a natural complement to the exfoliation and delivery work done by the spicules.
Betaine Salicylate (BHA) offers gentle chemical exfoliation. As an oil-soluble acid, it penetrates inside the pore to dissolve sebum buildup and dead skin cell congestion — the root cause of persistent enlarged pores and blackheads. Less aggressive than traditional salicylic acid, it delivers effective results with a lower risk of irritation.
Gluconolactone (PHA) is the mildest of the three acid types and works at the skin's surface to gently loosen and remove dead skin cells. PHAs are uniquely suited to sensitive skin as they have a larger molecular structure and cannot penetrate as deeply, making them effective without compromising the skin barrier.
Citric Acid (AHA) works alongside the other exfoliants to refine texture, improve cell turnover, and contribute to the overall brightening effect of the formula.
Panthenol (Provitamin B5) counterbalances the exfoliating actives by soothing, conditioning, and supporting moisture retention — essential for keeping the skin comfortable and healthy during regular exfoliation.
Adenosine brings anti-aging benefits, working to visibly soften fine lines and improve the overall smoothness of the skin surface with consistent use.
A blend of five botanical extracts — Evening Primrose, Kudzu Root, Pine Leaf, Chinese Trumpet Creeper, and Siberian Elm — round out the formula with antioxidant protection, skin-calming properties, and additional barrier support.
Clinical Results at a Glance
Medicube's clinical testing produced measurable results across multiple skin concerns. Dead skin cell removal improved by 88.7%, skin radiance increased by 51.7%, and the skin barrier strengthened by 54.2%. Sebum production decreased by 8.9%, visible skin texture refined by 4.1%, and melanin pigmentation visibility reduced by 7.4%. Pore density and pore visibility each decreased by 21.1%.
Active ingredient absorption improved by 242% compared to using the same skincare products without the Exosome Shot.
Results from a consumer use study. Individual results may vary.
The Tingling Sensation: What to Expect
First-time users almost always notice a tingling, warming, or mild itching sensation during application. This is completely expected and temporary — it's the spicule particles creating micro-channels in the skin surface and the exosomes beginning their delivery process. The sensation typically subsides within a short time after application.
For very sensitive skin, starting with 2–3 uses per week and gradually increasing frequency gives the skin time to adjust before daily use.
Two Ways to Use It
Beginner (Targeted): After cleansing and toning, apply the Exosome Shot to specific areas of concern — enlarged pores, uneven texture, or congested zones. Gently press and massage until absorbed, then follow with your regular moisturiser. Do not combine with AGE-R devices until skin has fully adjusted to the formula.
Standard (Full Face): After cleansing, apply to the entire face as the first step in your routine, avoiding the eye and lip area. Massage gently with both hands until absorbed, then layer your remaining skincare on top. The micro-channels created by the spicules will enhance absorption of everything that follows.
Pro Tip: Apply after using the AGE-R Booster Pro in Air Shot Mode to maximise the depth of penetration and the efficacy of the entire routine.
Who This Is For
The Medicube One Day Exosome Shot 2000 is ideal for anyone dealing with visibly enlarged pores, rough or uneven skin texture, dullness and lacklustre tone, congestion and excess sebum, fine lines and early signs of aging, or skin that absorbs product poorly. It is hypoallergenic, non-comedogenic, gluten-free, and free from artificial colourants — suitable for all skin types including sensitive and acne-prone skin.
Product Details
- Brand: Medicube (South Korea)
- Size: 30ml
- Exosome Concentration: 2000ppm
- Skin Type: All skin types including sensitive and acne-prone
- Free From: Artificial colourants, gluten
- Hypoallergenic Tested: Yes | Non-Comedogenic: Yes
Ingredients:
Water, Dipropylene Glycol, Glycerin, Butylene Glycol, 1,2-Hexanediol, Niacinamide, Sodium Polyacrylate, Ethylhexyl Palmitate, C12-14 Alketh-12, Hydrogenated Polydecene, Hydrolyzed Sponge, Ethylhexylglycerin, Adenosine, Caprylyl/Capryl Glucoside, Disodium EDTA, Panthenol, Lactobacillus Extracellular Vesicles, Campsis Grandiflora Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis (Evening Primrose) Flower Extract, Ulmus Davidiana Root Extract, Calcium Silicate, Sodium Silicate, Betaine Salicylate, Citric Acid, Gluconolactone
Formulation is subject to change at the manufacturer's discretion. Always refer to the product packaging for the most current ingredient information.